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A gene panel is a diagnostic tool that involves sequencing a selected group of genes that are known to be associated with specific diseases or conditions. These panels are widely used in clinical settings to diagnose genetic disorders, guide treatment decisions, and assess disease risk. Unlike whole-genome or whole-exome sequencing, which analyze large sections of the genome, gene panels focus only on relevant genes, making them more cost-effective and faster. They are especially common in oncology, cardiology, and rare disease diagnostics, where identifying mutations in key genes can significantly influence patient care and management.

Gene panels can be either targeted (focusing on a small number of genes) or comprehensive (covering a broader set of genes associated with a condition). Advances in next-generation sequencing (NGS) technology have improved the accuracy and efficiency of gene panel testing. Clinicians use these panels not only to confirm a diagnosis but also to predict disease progression or identify individuals at higher risk, especially in hereditary cancers. Moreover, gene panels can be tailored to a patient's symptoms or family history, enhancing the precision of personalized medicine.

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